Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress
文献类型： 外文期刊
第一作者： Zhang, Sai-Yang
作者： Zhang, Sai-Yang;Xie, Han-Zhong;Zhang, Sai-Yang;Fu, Dong-Jun;Li, Ping;Song, Jian;Zhang, Sai-Yang;Fu, Dong-Jun;Li, Ping;Song, Jian;Zhang, Sai-Yang;Fu, Dong-Jun;Li, Ping;Song, Jian;Zhang, Sai-Yang;Fu, Dong-Jun;Li, Ping;Song, Jian;Zhang, Sai-Yang;Zhang, Sai-Yang;Zhang, Sai-Yang;Xie, Han-Zhong
作者机构：
关键词： Chlorpyrifos; Carbofuran; Synergistic neurotoxicity; Apoptosis; Cycle arrest; Oxidative stress
期刊名称：TOXICOLOGY IN VITRO （ 影响因子：3.5； 五年影响因子：3.701 ）
ISSN： 0887-2333
年卷期： 2019 年 54 卷
页码：
收录情况： SCI
摘要： Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. The toxicity was partly depending on oxidative stress (OS) and had effects on cell apoptosis and cell cycle arrest. Furthermore, the toxicity remained on long-term low-dose condition.
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