Dietary supplemental vitamin D-3 enhances phosphorus absorption and utilisation by regulating gene expression of related phosphate transporters in the small intestine of broilers

文献类型： 外文期刊

第一作者： Shao, Yuxin

作者： Shao, Yuxin;Wen, Qian;Zhang, Shumin;Lu, Lin;Mang, Liyang;Liao, Xiudong;Luo, Xugang

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关键词： Vitamin D-3; Phosphorus; Absorption; Utilisation; Sodium-dependent phosphate cotransporters; Broilers

期刊名称：BRITISH JOURNAL OF NUTRITION （ 影响因子：3.718； 五年影响因子：4.816 ）

ISSN： 0007-1145

年卷期： 2019 年 121 卷 1 期

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收录情况： SCI

摘要： The present study was carried out to evaluate the effect of dietary supplemental vitamin D-3 (VD3) on P absorption and utilisation as well as its related mechanisms in the small intestine of broilers. A total of 384 1-d-old Arbor Acres male broilers were assigned randomly into four treatments following a completely randomised design with a 2 (dietary non-phytate P (NPP) contents: 0.43 and 0.22%) x 2 (dietary VD3 supplemental levels: 0 and 87.5 mu g/kg) factorial arrangement. The experiment lasted for 22 d. The results showed that P contents in serum from the hepatic portal vein and tibia ash of broilers were higher (P<0.05) for 0.43% NPP than for 0.22% NPP. The type IIb Na-dependent phosphate cotransporter (NaP-IIb) protein expressions in the duodenum and ileum were higher (P<0.05) also for 0.43% NPP than 0.22% NPP.Supplementation of VD3 enhanced (P<0.05) tibia P retention rate and type III Na-dependent phosphate cotransporter (PiT)-1 protein expression in the duodenum of all broilers. Moreover, VD3 supplementation decreased (P<0.002) mortality and increased (P<0.02) serum P content from the hepatic portal vein after 4 h of feeding, tibia ash content, tibia ash P content and protein expressions of NaP-IIb and PiT-1 in the jejunum of broilers fed diet with 0.22% NPP. Thus, dietary supplemental VD3 promoted intestinal P absorption and bone P utilisation, and this effect might be associated with enhanced PiT-1 levels in the duodenum and PiT-1 and NaP-IIb levels in the jejunum respectively when dietary NPP is limiting.

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