Royal Jelly Alleviates Cognitive Deficits and beta-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis

文献类型： 外文期刊

第一作者： You, Mengmeng

作者： You, Mengmeng;Pan, Yongming;Liu, Yichen;Chen, Yifan;Wu, Yuqi;Si, Juanjuan;Hu, Fuliang;Wang, Kai

作者机构：

关键词： royal jelly; Alzheimer's disease; cognitive deficits; amyloid-beta; cAMP-response element binding protein; apoptosis

期刊名称：FRONTIERS IN AGING NEUROSCIENCE （ 影响因子：5.75； 五年影响因子：5.913 ）

ISSN： 1663-4365

年卷期： 2019 年 10 卷

页码：

收录情况： SCI

摘要： Alzheimer's disease (AD) is characterized clinically by progressive cognitive decline and pathologically by the accumulation of amyloid-beta (A beta) in the brain. Royal jelly (RJ), a secretion of honeybee hypopharyngeal and mandibular glands, has previously been shown to have anti-aging and neuromodulatory activities. In this study, we discovered that 3 months of RJ treatment substantially ameliorated behavioral deficits of APP/PS1 mice in the Morris Water Maze (MWM) test and step-down passive avoidance test. Our data also showed that RJ significantly diminished amyloid plaque pathology in APP/PS1 mice. Furthermore, RJ alleviated c-Jun N-terminal kinase (JNK) phosphorylation-induced neuronal apoptosis by suppressing oxidative stress. Importantly, hippocampal cyclic adenosine monophosphate (cAMP), p-PKA, p-CREB and BDNF levels were significantly increased in the APP/PS1 mice after RJ treatment, indicating that the cAMP/PKA/CREB/BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline. Collectively, these results provide a scientific basis for using RJ as a functional food for targeting AD pathology.

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