Vaccination of poultry successfully eliminated human infection with H7N9 virus in China

文献类型： 外文期刊

第一作者： Zeng, Xianying

作者： Zeng, Xianying;Tian, Guobin;Shi, Jianzhong;Deng, Guohua;Li, Chengjun;Chen, Hualan

作者机构：

关键词： H7N9 influenza virus; evolution; vaccination; human infection; elimination

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：6.038； 五年影响因子：4.754 ）

ISSN： 1674-7305

年卷期： 2018 年 61 卷 12 期

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收录情况： SCI

摘要： The H7N9 viruses that emerged in China in 2013 were nonpathogenic in chickens but mutated to a highly pathogenic form in early 2017 and caused severe disease outbreaks in chickens. The H7N9 influenza viruses have caused five waves of human infection, with almost half of the total number of human cases (766 of 1,567) being reported in the fifth wave, raising concerns that even more human infections could occur in the sixth wave. In September 2017, an H5/H7 bivalent inactivated vaccine for chickens was introduced, and the H7N9 virus isolation rate in poultry dropped by 93.3% after vaccination. More importantly, only three H7N9 human cases were reported between October 1, 2017 and September 30, 2018, indicating that vaccination of poultry successfully eliminated human infection with H7N9 virus. These facts emphasize that active control of animal disease is extremely important for zoonosis control and human health protection.

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