Pharmacokinetic profiles of florfenicol in spotted halibut, Verasper variegatus, at two water temperatures

文献类型： 外文期刊

第一作者： Chang, Zhiqiang

作者： Chang, Zhiqiang;Chen, Zhao;Gao, Haiyu;Zhai, Qianqian;Li, Jian;Chang, Zhiqiang;Zhai, Qianqian;Li, Jian;Chen, Zhao;Gao, Haiyu

作者机构：

关键词： florfenicol; pharmacokinetics; spotted halibut; temperature

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2019 年 42 卷 1 期

页码：

收录情况： SCI

摘要： The pharmacokinetic profiles of florfenicol in the spotted halibut (Verasper variegatus) were investigated at 15 and 20 degrees C water temperatures, respectively. Florfenicol content in plasma samples was analyzed using an HPLC method. Drug concentration versus time data were best fitted to a three-compartment model after a single intravenous administration (15 mg/kg BW), and fitted to a two-compartment model after an oral administration (30 mg/kg BW) at 15 and 20 degrees C. The florfenicol concentration in the blood increased slowly during the 12 hr following an oral administration at 15 degrees C, with a peak concentration (C-max) of 9.1 mg/L, and then declined gradually. The half-lives of absorption, distribution, and elimination phase were 2.18, 5.66 and 14.25 hr, respectively. The bioavailability (F) was calculated to be 24.14%. After an oral administration at 20 degrees C, shorter half-lives of absorption (1.33 hr), distribution (2.51 hr) and elimination (9.71 hr), a higher C-max (12.2 mg/L), and a similar F (23.98%) were found. Based on the pharmacokinetics and pharmacodynamics, an oral dose of 30 mg/kg BW was suggested to be efficacious for bacterial disease control in spotted halibut farming.

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