Distinct Patterns of PPAR Promoter Usage, Lipid Degradation Activity, and Gene Expression in Subcutaneous Adipose Tissue of Lean and Obese Swine

文献类型： 外文期刊

第一作者： Song, Bin

作者： Song, Bin;Di, Shengwei;Cui, Shiquan;Huang, Xuankai;Liu, Jun;Wang, Xibiao;Song, Bin;Tong, Guizhi;Wang, Hongbao;Huang, Xuankai;Ding, Liyan;Chen, Na;Wang, Xuan;Gao, Qian;Gao, Ying;Liu, Jun;Wang, Huan;Wang, Xuan

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关键词： pig; subcutaneous adipose tissue; transcriptome; fatty acid degradation; PPAR

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2018 年 19 卷 12 期

页码：

收录情况： SCI

摘要： Subcutaneous adipose tissue is a loose connective tissue specializing in the regulation of energy storage and metabolization. In domesticated pigs (Sus scrofa), the temporal development of subcutaneous adipose tissue is critical for meat production. However, the regulation of adipose tissue development remains unclear. Here, the subcutaneous adipose tissue development was characterized and compared in lean (Danish-Landrace) and obese (Min) pigs at juvenile and the juvenile-to-adult growth stages. Using RNA sequencing, we profiled the transcriptome of subcutaneous adipose tissue isolated from 4- and 16-week-old pigs and identified 24,718 expressed transcription units. Of them, 6327 genes were differentially expressed between the breeds and/or developmental stages. Compared with obese pigs, upregulated genes in lean pigs showed significant function and pathway enrichment in fatty acid degradation and mitochondrial functions. Further analysis uncovered the distinct usage preferences of the three alternative peroxisomeproliferator-activatedreceptor (PPAR) promoters associated with the development of subcutaneous adipose tissue in both breeds. Transcriptome analysis of subcutaneous adipose tissue in lean and obese pigs suggested that marker-assisted selection of fatty acid degradation and PPAR signaling pathways could be important directions for future pork quality improvement and modern breeding.

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