Gas phase reaction between chromones and solvent in an electrospray ionization source

文献类型： 外文期刊

第一作者： Liu, Zhen

作者： Liu, Zhen;Shao, Yunlong;Zhu, Guizhen;Wang, Xiayan;Wang, Lin;Chai, Yunfeng

作者机构：

关键词： chromones; covalent/noncovalent adduct; electrospray ionization; in-source reaction

期刊名称：JOURNAL OF MASS SPECTROMETRY （ 影响因子：1.982； 五年影响因子：2.03 ）

ISSN： 1076-5174

年卷期： 2019 年 54 卷 1 期

页码：

收录情况： SCI

摘要： Chromones were measured by using electrospray ionization mass spectrometry in negative mode. Interestingly, in addition to the deprotonated ion ([M - H](-)), unexpected [M + 17](-) and [M + 31](-) ions were observed in high intensity when water and methanol were used as the solvent. Chromones with different substitutes were tested. Compared with the deprotonated ion, [M + 17](-) and [M + 31](-) ions were observed with higher abundances when the C-3 site of chromones was substituted by electron withdrawing groups. Based on high performance liquid chromatography-mass spectrometry (LC-MS), deuterium-labeling and collisional-induced dissociation experiments, a covalent gas-phase nucleophilic addition reaction between chromone and water, and the formation of a noncovalent complex between chromone and methanol were proposed as the mechanism for the observed [M + 17](-) and [M + 31](-) ions, respectively. Understanding and using these unique gas phase reactions can avoid misannotation when analyzing chromones and their metabolites.

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