A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity

文献类型： 外文期刊

第一作者： Zhang, Yingyu

作者： Zhang, Yingyu;Li, Qi;Wang, Fengzhong;Xing, Cencan

作者机构：

关键词： Food and drugs; High-throughput analysis; Acute hyperuricemia; Model; Zebrafish

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2019 年 508 卷 2 期

页码：

收录情况： SCI

摘要： With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time. The results show PO 200 mu M + XSS 10 mu M, PO 300 mu M + XSS 15 mu M, and PO 400 mu M + XSS 20 mu M can significantly increase the level of uric acid in the zebrafish larvae (P < 0.05), the concentrations as described above can be used to construct the zebrafish larvae model of acute hyperuricemia. At the same time, treatment of allopurinol (APL, one of the hyperuricemia drugs) at 2000 mu M (P < 0.001) and treatment of anserine (ASE) at 200 mu M (P < 0.05) could significantly decrease the level of uric acid in the model group which received PO 200 mu M + XSS 10 mu M, which demonstrate that such model could offer a new robust approach for high-throughput screening of food and drugs with uric acid-lowering activity. (C) 2018 Published by Elsevier Inc.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序