The high conserved cellular receptors of avian leukosis virus subgroup J in Chinese local chickens contributes to its wide host range

文献类型： 外文期刊

第一作者： Zhang, Yao

作者： Zhang, Yao;Guan, Xiaolu;Leghari, Muhammad Farooque;Wang, Yongqiang;Qi, Xiaole;Wang, Xiaomei;Gao, Yulong;Chen, Zhiwu;Shen, Qiancheng;Cao, Dingguo;Lei, Qiuxia;Li, Fuwei;Kang, Zhaofeng;Li, Haiqin

作者机构：

关键词： Subgroup J avian leukosis virus; chNHE1; chANXA2; cellular receptor; epidemiology

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN： 0032-5791

年卷期： 2018 年 97 卷 12 期

页码：

收录情况： SCI

摘要： Avian leukosis virus (ALV) is a tumor-inducing virus that spreads among most chicken species, causing serious financial losses for the poultry industry. Subgroup J avian leukosis virus (ALV-J) is a recombinant exogenous ALV, which shows more extensive host range in comparison with other subgroups, especially in Chinese local chickens. To identify the relationship between ALV-J host range and the polymorphism of its cellular receptors, we performed a wide range epidemiological investigation of current ALV-J infection in Chinese local chickens, and discovered that all the 18 local chicken breeds being investigated from main local chicken breeding provinces were ALV-J positive. Furthermore, we cloned ALV-J cellular receptor genes of chNHE1 and chANXA2 of these 18 chicken breeds. Sequence alignment demonstrated that despite several regular mutations at the nucleotide level, there were no corresponding amino acid mutations for either chNHE1 gene or chANXA2 gene. Additionally, virus entry assay indicated that the level of viral enter into cells is stable among different chicken breeds. Results of this study indicated that the wide host range of ALV-J in Chinese local chickens was partially due to the high conservatism of its cellular receptors, and also provide target sites for drug design of resistance to ALV-J infection.

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