In vitro antioxidant and immunostimulating activities of polysaccharides from Ginkgo biloba leaves

文献类型： 外文期刊

第一作者： Ren, Qi

作者： Ren, Qi;Dai, Qianying;Ding, Zhien;Chen, Jing;Ding, Zhenhua;Ding, Yu;Cheng, Jianghua;Yang, Song

作者机构：

关键词： Ginkgo biloba; Polysaccharides; Antioxidant activity; Immunostimulating activity

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2019 年 124 卷

页码：

收录情况： SCI

摘要： Ginkgo biloba leaves (GBLs) are used as herbal dietary supplements and medicine worldwide. In this study, crude GBL polysaccharides (GBPSs) were extracted and further purified on a DEAE (diethylaminoethanol) Sepharose Fast Flow column to obtain GBPS-2 and GBPS-3. The molecular weights of GBPS-2 and GBPS-3 were 672 and 723 kDa, respectively. GBPS-2 and GBPS-3 were typical acidic heteropolysaccharides, composed of mannose (Man), rhamnose (Rha), glucuronic acid (GIcA), galacturonic acid (GalA), glucose (Glc), galactose (Gal), and arabinose (Ara) (molar ratio: 0.08:0.12:0.16:0.06:0.11:1.00:032) and Man, Rha, GLcA, GalA, Gal, and Ara (molar ratio: 0.92:1.00:0.83:0.11:0.42:0.23), respectively. GBPS-2 and GBPS-3 exhibited limited scavenging abilities for the hydroxyl and 2,2-diphenyl-1-picrylhydrazyl radicals as well as noticeable scavenging effects on superoxide radicals and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radicals. Furthermore, GBPS-2 and GBPS-3 significandy increased the phagocytosis of macrophages and promoted the production of NO, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, and IL-6. Thus, GBPS-2 and GBPS-3 exhibit potential application as functional food supplements. (C) 2018 Published by Elsevier B.V.

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