The Anaplasma ovis genome reveals a high proportion of pseudogenes

文献类型： 外文期刊

第一作者： Liu, Zhijie

作者： Liu, Zhijie;Yang, Jifei;Li, Youquan;Guan, Guiquan;Luo, Jianxun;Yin, Hong;Peasley, Austin M.;Brayton, Kelly A.;Yin, Hong

作者机构：

关键词： Genome sequence; Comparative genomics; Vaccine development; Diagnostic assay; Rickettsial pathogen

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2019 年 20 卷

页码：

收录情况： SCI

摘要： Background: The genus Anaplasma is made up of organisms characterized by small genomes that are undergoing reductive evolution. Anaplasma ovis, one of the seven recognized species in this genus, is an understudied pathogen of sheep and other ruminants. This tick-borne agent is thought to induce only mild clinical disease; however, small deficits may add to larger economic impacts due to the wide geographic distribution of this pathogen. Results: In this report we present the first complete genome sequence for A. ovis and compare the genome features with other closely related species. The 1,214,674 bp A. ovis genome encodes 933 protein coding sequences, the split operon arrangement for ribosomal RNA genes, and more pseudogenes than previously recognized for other Anaplasma species. The metabolic potential is similar to other Anaplasma species. Anaplasma ovis has a small repertoire of surface proteins and transporters. Several novel genes are identified. Conclusions: Analyses of these important features and significant gene families/genes with potential to be vaccine candidates are presented in a comparative context. The availability of this genome will significantly facilitate research for this pathogen.

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