Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

文献类型： 外文期刊

第一作者： Wang, Pei

作者： Wang, Pei;Cui, Yan;Cai, Caihong;Chen, Huiqin;Dai, Yu;Chen, Pengwei;Kong, Fandong;Yuan, Jingzhe;Mei, Wenli;Dai, Haofu;Wang, Pei;Cui, Yan;Cai, Caihong;Chen, Huiqin;Dai, Yu;Chen, Pengwei;Kong, Fandong;Yuan, Jingzhe;Mei, Wenli;Dai, Haofu;Song, Xinming;Song, Xinming

作者机构：

关键词： mangrove-derived fungus; Cladosporium sp; succinimide-containing derivatives; cytotoxicity; alpha-glycosidase inhibitor

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2019 年 17 卷 1 期

页码：

收录情况： SCI

摘要： Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 +/- 0.35 M, 25.6 +/- 0.47 M, and 41.7 +/- 0.71 M, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 +/- 0.21 M and 26.7 +/- 1.1 M, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against -glycosidase, with IC50 values of 78.2 +/- 2.1 M and 49.3 +/- 10.6 M, respectively.

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