Linseed oil improves hepatic insulin resistance in obese mice through modulating mitochondria' quality control

文献类型： 外文期刊

第一作者： Yu, Xiao

作者： Yu, Xiao;Deng, Qianchun;Tang, Hu;Dong, Xuyan;Yu, Xiao;Deng, Qianchun;Tang, Hu;Dong, Xuyan;Yu, Xiao;Huang, Shasha;Yu, Xiao;Huang, Shasha;Tang, Yuhan;Yao, Ping;Tang, Yuhan;Yao, Ping

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关键词： Linseed oil; Diet; High-fat; Insulin resistance; Mitochondria

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2019 年 53 卷

页码：

收录情况： SCI

摘要： N-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), mitigate the progression of obesity-associated insulin resistance. However, the knowledge on the metabolic response and underlying mechanism of a-linolenic acid-rich linseed oil (ALA-LO) on insulin resistance was still limited. The results showed that lard-based high fat diet (HFD) feeding for 16 weeks (60% of total calories from fat) led to imbalanced lipid synthesis-oxidation, defect insulin signaling and serious mitochondrial damage in mice liver, which was attenuated by LO. Moreover, LO blocked chronic HFD-induced mitophagy suppression, and improved mitochondrial biogenesis and fusion process in mice liver. Importantly, the specific location of ALA, and its n-3 derivatives docosapentenoic acid (DPA) and DHA in mitochondrial membrane was observed, concomitant with upregulation of SIRT1, PPAR gamma coactivator-1 alpha (PGC-alpha) and extracellular signal regulated kinase (ERK) in mice liver. LO improves hepatic insulin resistance in obese mice partly by restoring mitochondrial quality control network.

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