Lactoferrin: Major Physiological Functions and Applications

文献类型： 外文期刊

第一作者： Hao, Liyuan

作者： Hao, Liyuan;Shan, Qiang;Wei, Jingya;Ma, Fengtao;Sun, Peng

作者机构：

关键词： Lactoferrin (Lf); iron-binding activity; immunomodulatory function; anti-microbial effect; anti-viral effect; antioxidant effect; anti-cancer effect; application

期刊名称：CURRENT PROTEIN & PEPTIDE SCIENCE （ 影响因子：3.272； 五年影响因子：3.183 ）

ISSN： 1389-2037

年卷期： 2019 年 20 卷 2 期

页码：

收录情况： SCI

摘要： Lactoferrin (lactotransferrin; Lf) is an iron-binding glycoprotein and one of the most important bioactivators in milk and other external secretions. It has numerous biological roles, including the regulation of iron absorption and modulation of immune responses, and has anti-microbial, anti-viral, antioxidant, anti-cancer, and anti-inflammatory activities. Lf regulates the quantity of iron absorbed in the intestine via its role in iron transport and can also chelate iron, directly or indirectly. Notably, it has been used as an adjuvant therapy for some intestinal diseases. It is now used in nutraceutical-supplemented infant formula and other food products. This article reviews the content, distribution, physiologic functions and current applications of Lf, and aims to shed light on future prospects for additional applications of Lf.

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