Biphasic recognition chiral extraction of threonine enantiomers in a two- phase system formed by hydrophobic and hydrophilic deep-eutectic solvents

文献类型： 外文期刊

第一作者： Wang, Chaoyun

作者： Wang, Chaoyun;Tan, Zhijian;Wang, Chaoyun;Tan, Zhijian;Wang, Runping;Sun, Danyu;Liu, Lianglei;Li, Fenfang

作者机构：

关键词： Biphasic recognition chiral extraction; Enantioselective liquid-liquid extraction; Two-phase system; Deep-eutectic solvents; Threonine enantiomers

期刊名称：SEPARATION AND PURIFICATION TECHNOLOGY （ 影响因子：7.312； 五年影响因子：6.656 ）

ISSN： 1383-5866

年卷期： 2019 年 215 卷

页码：

收录情况： SCI

摘要： Recently, deep-eutectic solvents (DESs) were considered as excellent substitutes for conventional organic solvents and ionic liquids (ILs) used in the extraction field. Therefore, the biphasic recognition chiral extraction (BRCE) systems formed by hydrophilic and hydrophobic DESs were developed for the enantioseparation of threonine enantiomers in this study. The chiral selectors of ( + )-Diisopropyl L-tartrate (DIPT) and Hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) were added to the hydrophobic phase and the hydrophilic phase, respectively. The factors influencing the chiral separation effect were investigated, including type of DESs, phase volume ratio, water content in BRCE, chiral selectors concentration, initial threonine concentration, system pH, and extraction temperature. The two-phase system of ( - )-Menthol-L( + )-Lactic acid/Choline chloride-Urea (M - LA/ChCl-U) was screened as the optimum BRCE system. The maximum enantiomeric excess (e.e.) value of 31.6% was obtained under the optimized conditions. The enantioseparation of threonine enantiomers can be achieved by a single step extraction, and thus this BRCE based on DESs is simple, efficient, and environmentally friendly.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序