A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro

文献类型： 外文期刊

第一作者： Li, Shi-fang

作者： Li, Shi-fang;Gong, Mei-jiao;Xie, Yin-li;Shao, Jun-jun;Zhao, Fu-rong;Zhang, Yong-guang;Chang, Hui-yun;Li, Shi-fang;Xie, Yin-li;Shao, Jun-jun;Zhao, Fu-rong;Zhang, Yong-guang;Chang, Hui-yun;Gong, Mei-jiao

作者机构：

关键词： Type I interferon; PoIFN-alpha omega; Foot and mouth disease virus; Interferon stimulated genes; Antiviral activity; IFN-mu

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2019 年 127 卷

页码：

收录情况： SCI

摘要： Recently, a novel type I interferon alphaomega (IFN-alpha omega), also known as IFN-mu, was identified. However, the biological activity of IFN-alpha omega remain poorly understood. In this study, the porcine IFN-alpha omega (PoIFN-alpha omega) was expressed, purified, and its antiviral activities assessed by its ability to inhibit the cytopathic effect caused by FMDV on IBRS-2 cells. In addition, q-PCR was used to evaluate the expression of IFN-stimulated genes induced by PoIFN-alpha omega. It was found that PoIFN-alpha omega exerted effective antiviral activity against FMDV pre- and post-infection. Additionally, PoIFN-alpha omega induced the transcription of IFN-stimulated genes, including Mx1, ISG15, OAS1, and PKR genes. Our study reported a new indication of PoIFN-alpha omega as an effective anti-FMDV agent for the first time.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序