Development of a 38 K single nucleotide polymorphism array and application in genomic selection for resistance against Vibrio harveyi in Chinese tongue sole, Cynoglossus semilaevis

文献类型： 外文期刊

第一作者： Lu, Sheng

作者： Lu, Sheng;Zhou, Qian;Chen, Yadong;Liu, Yang;Li, Yangzhen;Wang, Lei;Yang, Yingming;Chen, Songlin;Lu, Sheng;Zhou, Qian;Chen, Yadong;Liu, Yang;Li, Yangzhen;Wang, Lei;Yang, Yingming;Chen, Songlin;Lu, Sheng;Lu, Sheng;Zhou, Qian;Chen, Yadong;Liu, Yang;Li, Yangzhen;Wang, Lei;Yang, Yingming;Chen, Songlin

作者机构：

关键词： SNP array; Genomic selection; Disease resistance; Cynoglossus semilaevis; Vibrio harveyi

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2021 年 113 卷 4 期

页码：

收录情况： SCI

摘要： Based on 1572 re-sequenced Chinese tongue sole (Cynoglossus semilaevis), we investigated the accuracy of four genomic methods at predicting genomic estimated breeding values (GEBVs) of Vibrio harveyi resistance in C. semilaevis when SNPs varying from 500 to 500 k. All methods outperformed the pedigree-based best linear un-biased prediction when SNPs reached 50 k or more. Then, we developed an SNP array "Solechip No.1" for C. semilaevis breeding using the Affymetrix Axiom technology. This array contains 38,295 SNPs with an average of 10.5 kb inter-spacing between two adjacent SNPs. We selected 44 candidates as the parents of 23 families and genotyped them by the array. The challenge survival rates of offspring families had a correlation of 0.706 with the mid-parental GEBVs. This SNP array is a convenient and reliable tool in genotyping, which could be used for improving V. harveyi resistance in C. semilaevis coupled with the genomic selection methods.

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