Predicting cadmium and lead toxicities in zebrafish (Danio rerio) larvae by using a toxicokinetic-toxicodynamic model that considers the effects of cations

文献类型： 外文期刊

第一作者： Feng, Jianfeng

作者： Feng, Jianfeng;Chen, Min;Xu, Xin;Huang, Mengdi;Yang, Tong;Chen, Na;Zhu, Lin;Feng, Jianfeng;Chen, Min;Xu, Xin;Huang, Mengdi;Yang, Tong;Chen, Na;Zhu, Lin;Gao, Yongfei

作者机构：

关键词： Toxicokinetic-toxicodynamic (TK-TD) model; Competitive cations; Zebrafish larvae; Accumulation; Toxicity

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）

ISSN： 0048-9697

年卷期： 2018 年 625 卷

页码：

收录情况： SCI

摘要： Protons and cations may affect metal accumulation in aquatic organisms and further influence metal toxicity. The effects of K+ Na+, Ca2+ Mg2+, and Hi on the accumulation and toxicity of Cd and Pb in zebrafish larvae after 24 h exposure were examined. We found that Na Ca2+ Mg2+, and H exerted significant effects on both the accumulation and toxicity of Cd, and Ca2+ Mg2+, and H ' also affected both the accumulation and toxicity of Pb significantly. Subsequently, stability constants for the binding of Pb2+ Cd2+ Kl, Ca2+ Mg2+', Na2+ and Hi lo biotic ligand were estimated with the Langmuir model and biotic ligand model (BLM). Using the BLM-estimated binding constants calculated with toxicity data, a refined loxicokinetic-Loxicoclynamic (TK-TD) model considering cation competition effects was used to predict Cd and Pb accumulation and survival rates in zebrafish larvae with varying cation concentrations. Results showed that the developed TK-TD model could successfully predict Cd and Pb toxicity to zebrafish larvae as a function of major competitive cations. The TK-TD model incorporated cation competition effects is a promising tool to quantify and assess the metal risk in natural water. (C) 2018 Elsevier B.V. All rights reserved.

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