Immunity against hepatitis E virus infection: Implications for therapy and vaccine development
文献类型： 外文期刊
第一作者： Hakim, Mohamad S.
作者： Hakim, Mohamad S.;Ikram, Aqsa;Zhou, Jianhua;Wang, Wenshi;Peppelenbosch, Maikel P.;Pan, Qiuwei;Hakim, Mohamad S.;Ikram, Aqsa;Zhou, Jianhua;Wang, Wenshi;Peppelenbosch, Maikel P.;Pan, Qiuwei;Hakim, Mohamad S.;Ikram, Aqsa;Zhou, Jianhua
作者机构：
关键词： adaptive immunity; hepatitis E virus; innate immunity; therapy; vaccine
期刊名称：REVIEWS IN MEDICAL VIROLOGY （ 影响因子：6.989； 五年影响因子：6.436 ）
ISSN： 1052-9276
年卷期： 2018 年 28 卷 2 期
页码：
收录情况： SCI
摘要： Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vaccines and immune-based therapies.
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