Topical delivery of L-theanine ameliorates TPA-induced acute skin inflammation via downregulating endothelial PECAM-1 and neutrophil infiltration and activation

文献类型： 外文期刊

第一作者： Zeng, Wei-Jie

作者： Zeng, Wei-Jie;Tan, Zhi;Xu, Ya-Nan;Mai, Chun-Lin;Zhang, Jun;Lin, Zhen-Jia;Liu, Xian-Guo;Zhou, Li-Jun;Zeng, Wei-Jie;Tan, Zhi;Xu, Ya-Nan;Mai, Chun-Lin;Zhang, Jun;Lin, Zhen-Jia;Liu, Xian-Guo;Zhou, Li-Jun;Lai, Xing-Fei;Sun, Shi-Li

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关键词： L-theanine; Anti-inflammatory; Neutrophil; Ear edema; Pro-inflammatory cytokine; PECAM-1

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.192； 五年影响因子：4.61 ）

ISSN： 0009-2797

年卷期： 2018 年 284 卷

页码：

收录情况： SCI

摘要： L-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of L-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 mu g/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of L-theanine 30 min before TPA time-and dose-dependently suppressed the increases in both skin thickness and weight. Subsequently L-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL1-beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils. It highlighted the potential of L-theanine as a locally administrable therapeutic agent for acute cutaneous inflammation.

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