Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice

文献类型： 外文期刊

第一作者： Huang, Guangping

作者： Huang, Guangping;Zhang, Sixin;Zhou, Chunxue;Tang, Xiaoli;Li, Chao;Wang, Chaoyue;Tang, Xinming;Suo, Jingxia;El-Ashram, Saeed;Suo, Xun;Liu, Xianyong;Huang, Guangping;Zhang, Sixin;Zhou, Chunxue;Tang, Xiaoli;Li, Chao;Wang, Chaoyue;Tang, Xinming;Suo, Jingxia;El-Ashram, Saeed;Yu, Zhengquan;Suo, Xun;Liu, Xianyong;Jia, Yonggen;Cai, Jianping;Gupta, Nishith;Zhou, Chunxue;El-Ashram, Saeed

作者机构：

关键词： host-parasite interaction; gut microbiota; metabolic pathway; Eimeria falciformis; mouse

期刊名称：INFECTION AND IMMUNITY （ 影响因子：3.441； 五年影响因子：3.702 ）

ISSN： 0019-9567

年卷期： 2018 年 86 卷 5 期

页码：

收录情况： SCI

摘要： Coccidiosis, caused by different species of Eimeria parasites, is an economically important disease of poultry and livestock worldwide. Here we report previously unknown alterations in the gut microbes and metabolism of BALB/c mice infected with Eimeria falciformis. Specifically, we observed a significant shift in the abundance of cecal bacteria and disrupted metabolism in parasitized animals. The relative abundances of Lachnospiraceae bacterium NK4A136, Ruminiclostridium, Alistipes, and Lactobacillus declined in response to E. falciformis infection, whereas Escherichia, Shigella, Helicobacter, Klebsiella, and Bacteroides were increased. Carbohydrate and amino acid metabolites in the serum samples of infected mice were significantly altered compared to naive controls. Levels of amino acids, including asparagine, histidine, L-cysteine, tryptophan, lysine, glycine, serine, alanine, proline, ornithine, methionine, and valine, decreased on day 7 postinfection before returning to baseline on day 14. In addition, increased levels of indolelactate and mannitol and a reduced amount of oxalic acid indicated impaired carbon metabolism upon parasitic infection. These data demonstrate that intestinal coccidial infection perturbs the microbiota and disrupts carbon and nitrogen metabolism.

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