Spiciferone analogs from an endophytic fungus Phoma betae collected from desert plants in West China

文献类型： 外文期刊

第一作者： Tan, Xiang-Mei

作者： Tan, Xiang-Mei;Li, Lu-Ying;Wang, Meng-Hua;Zhang, Xiao-Yan;Xing, Xiao-Ke;Zou, Zhong-Mei;Ding, Gang;Tan, Xiang-Mei;Li, Lu-Ying;Wang, Meng-Hua;Zhang, Xiao-Yan;Xing, Xiao-Ke;Zou, Zhong-Mei;Ding, Gang;Sun, Li-Yan;Sun, Bing-Da;Niu, Shu-Bin;Sun, Wen-Song;Zhang, Gui-Shan;Deng, Hui

作者机构：

期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.649； 五年影响因子：2.772 ）

ISSN： 0021-8820

年卷期： 2018 年 71 卷 6 期

页码：

收录情况： SCI

摘要： Endophytic fungi from desert, arid, and grassland areas are an ecologically important but unique group with poor chemical investigation. During our ongoing study to mine bioactive secondary metabolites from unique fungal environments, a new shunt product spiciferone F (1) including two new analogs spiciferones G (2) and H (3) together with four known ones spiciferone A (4), spiciferol A (5), 6, and 7 were isolated from endophytic fungus Phoma betae inhabiting in plant Kalidium foliatum (Pall.) Moq from Ningxia Province of West China. The planar, relative, and absolute configurations of these new compounds were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and electronic circular dichroism experiments. According to the shunt products, intermediates and analogs isolated from this endophytic fungus, the possible biosynthetic pathway of spiciferones was reconstructed. Compounds 1-7 were evaluated cytotoxic activities against three cancer cell lines HCT 116, HeLa, and MCF7, and only did 1 display strong biological effect against MCF7 with a half-maximal inhibitory concentration value at 7.73 +/- 0.11 mu M compared with the cis-platinum (14.32 +/- 1.01 mu M).

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