The Xanthomonas effector XopK harbours E3 ubiquitin-ligase activity that is required for virulence

文献类型： 外文期刊

第一作者： Sun, Lifan

作者： Sun, Lifan;Wang, Kailun;Yang, Fan;Zhang, Jie;Zhou, Xiaogang;Liao, Haicheng;Yin, Junjie;Chen, Xuewei;Zhou, Xiaogang;Liao, Haicheng;Yin, Junjie;Chen, Xuewei;Zhou, Xiaogang;Wang, Kailun;Rong, Wei;Chen, Huamin

作者机构：

关键词： effector; OsSERK2; plant immunity; ubiquitination; Xanthomonas

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）

ISSN： 0028-646X

年卷期： 2018 年 220 卷 1 期

页码：

收录情况： SCI

摘要： Xanthomonas oryzae pv. oryzae is the causative agent of rice bacterial leaf blight. While the type III secretion system of X.oryzae pv. oryzae is essential for virulence, the biochemical activities and virulence mechanisms of non-transcription activator-like (non-TAL) effectors delivered by this system are largely unknown. Here, by screening for non-TAL effectors that contribute to X.oryzae pv. oryzae virulence, we revealed that Xanthomonas outer protein K (XopK) inhibits pathogen-associated molecular pattern-triggered immunity upstream of mitogen-activated protein kinase cascades. Specifically, XopK interacted with and directly ubiquitinated rice somatic embryogenic receptor kinase 2 (OsSERK2), resulting in its degradation. Accordingly, mutation of a putative ubiquitin-conjugation enzyme (E2) binding site abolished XopK-induced degradation of OsSERK2 and compromised XopK-dependent virulence. As crucial immune regulators associated with a multitude of immune receptors, SERKs have been shown to be perturbed by Pseudomonas effectors via different mechanisms. Our study revealed a distinct perturbation mechanism of SERK activity via ubiquitination achieved by Xanthomonas non-TAL effector.

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