TLR4 overexpression enhances saturated fatty acid-induced inflammatory cytokine gene expression in sheep

文献类型： 外文期刊

第一作者： Xu, Xue

作者： Xu, Xue;Liu, Shuang;Song, Xu-Ting;Zhang, Jia-Nan;Zhai, Yu-Fei;Yao, Yu-Chang;Xu, Xue;Liu, Shuang;Song, Xu-Ting;Zhang, Jia-Nan;Zhai, Yu-Fei;Yao, Yu-Chang;Qi, Mei-Yu;Lu, Ming-Hai;Han, Hong-Bing;Lian, Zheng-Xing

作者机构：

关键词： genetically modified sheep; inflammatory cytokine; saturated fatty acids; Toll-like receptor 4

期刊名称：EUROPEAN JOURNAL OF INFLAMMATION （ 影响因子：0.466； 五年影响因子：0.599 ）

ISSN： 2058-7392

年卷期： 2018 年 16 卷

页码：

收录情况： SCI

摘要： Saturated fatty acids (SFAs) can directly stimulate innate immune responses, thereby exacerbating inflammatory aspects of metabolic syndrome. Dietary SFAs act as ligands of Toll-like receptor 4 (TLR4), triggering associated signaling pathways. In this study, we investigated the role of TLR4 in palm oil SFA-associated inflammatory cytokine gene expression in monocytes/macrophages and adipose tissue using TLR4-overexpressing genetically modified sheep. SFA stimulation resulted in upregulation of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), interferon-gamma (IFN-gamma), and interleukin-10 (IL-10), and TLR4 overexpression enhanced such SFA-induced inflammatory cytokine expression. Moreover, SFAs markedly activated MyD88-dependent signaling, including IL-1 receptor-associated kinase 4 (IRAK4), TNF receptor-associated factor 6 (TRAF6), and nuclear factor-kappa B (NF-kappa B). Taken together, our results indicate that TLR4 overexpression enhances the SFA-induced inflammatory response through MyD88-dependent signaling in monocytes/macrophages and adipose tissue.

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