Biomineralization improves mechanical and osteogenic properties of multilayer-modified PLGA porous scaffolds

文献类型： 外文期刊

第一作者： Kong, Junchao

作者： Kong, Junchao;Chen, Zhuming;Huang, Rui;Chu, Jiaqi;Zhao, Mingyan;Kong, Junchao;Wei, Bo;Chen, Zhuming;Groth, Thomas;Groth, Thomas;Li, Lihua;He, Dongning

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关键词： Poly-(lactide-co-glycolide acid); biomineralization; layer by layer technique; mesenchymal stem cells; bone tissue engineering

期刊名称：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A （ 影响因子：4.396； 五年影响因子：4.205 ）

ISSN： 1549-3296

年卷期： 2018 年 106 卷 10 期

页码：

收录情况： SCI

摘要： Poly-(lactide-co-glycolide acid) (PLGA) has been widely investigated as scaffold material for bone tissue engineering owing to its biosafety, biodegradability, and biocompatibility. However, the bioinert surface of PLGA may fail in regulating cellular behavior and directing osteointegration between the scaffold and the host tissue. In this article, oxidized chondroitin sulfate (oCS) and type I collagen (Col I) were assembled onto PLGA surface via layer by layer technique (LbL) as an adhesive coating for the attachment of inorganic minerals. The multilayer-modified PLGA scaffold was mineralized in vitro to ensure the deposition of nanohydroxyapatite (nHAP). It was found that nHAP crystals were more uniformly and firmly attached on the multilayer-modified PLGA as compared with the pure PLGA scaffold, which remarkably improved PLGA surface and mechanical properties. Additionally, in vitro biocompatibility of PLGA scaffold, in terms of bone mesenchymal stem cells (BMSCs) attachment, spreading and proliferation was greatly enhanced by nHAP coating and multilayer deposition. Furthermore, the fabricated composite scaffold also shows the ability to promote the osteogenic differentiation of BMSCs through the up-regulation of osteogenic marker genes. Thus, this novel biomimetic composite scaffold might achieve a desirable therapeutic result for bone tissue regeneration. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2714-2725, 2018.

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