Caerin1.1 Suppresses the Growth of Porcine Epidemic Diarrhea Virus In Vitro via Direct Binding to the Virus

文献类型： 外文期刊

第一作者： Guo, Nan

作者： Guo, Nan;Zhang, Bingzhou;Hu, Han;Ye, Shiyi;Chen, Fangzhou;Li, Zhonghua;Chen, Pin;He, Qigai;Wang, Chunmei

作者机构：

关键词： antimicrobial peptides; Caerin1.1; porcine epidemic diarrhea virus

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN： 1999-4915

年卷期： 2018 年 10 卷 9 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea (PED) has re-emerged in recent years and has already caused huge economic losses to the porcine industry all over the world. Therefore, it is urgent for us to find out efficient ways to prevent and control this disease. In this study, the antiviral activity of a cationic amphibian antimicrobial peptide Caerin1.1 against porcine epidemic diarrhea virus (PEDV) was evaluated by an in vitro system using Vero cells. We found that even at a very low concentration, Caerin1.1 has the ability to destroy the integrity of the virus particles to block the release of the viruses, resulting in a considerable decrease in PEDV infections. In addition, Caerin1.1 showed powerful antiviral activity without interfering with the binding progress between PEDV and the receptor of the cells, therefore, it could be used as a potential antiviral drug or as a microbicide compound for prevention and control of PEDV.

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