文献类型： 外文期刊
第一作者： Pang, Dao-Ran
作者： Pang, Dao-Ran;Pan, Bo;Sun, Jing;Sun, Hui;Yao, Hui-Na;Song, Yue-Lin;Zhao, Yun-Fang;Tu, Peng-Fei;Zheng, Jiao;Li, Jun;Sun, Jing;Tu, Peng-Fei;Huang, Wen-Zhe
作者机构：
关键词： Chinese dragon's blood; Dracaena cochinchinensis; Meta-homoisoflavane; Homoisoflavanone; Anti-neuroinflammation
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2018 年 131 卷
页码：
收录情况： SCI
摘要： Five new homoisofiavonoid derivatives, including three meta-homoisoflavanes (1-3), one homoisoflavanone (4), and one homoisofiavan (5), along with five known analogues (6-10), were isolated from the red resin of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated by analysis of spectroscopic data (1D and 2D NMR, IR, and HRESIMS). The absolute configuration of compound 1 was determined by single crystal X-ray crystallographic analysis, and those of 2-5 were established on the basis of experimental and computed ECD data. Compounds 4, 6, and 9 exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values of 60.4-75.6 mu M.
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