Reversible Histone H2B Monoubiquitination Fine-Tunes Abscisic Acid Signaling and Drought Response in Rice

文献类型： 外文期刊

第一作者： Ma, Siqi

作者： Ma, Siqi;Tang, Ning;Li, Xu;Xie, Yongjun;Xiang, Denghao;Fu, Jie;Shen, Jianqiang;Yang, Jun;Tu, Haifu;Li, Xianghua;Hu, Honghong;Xiong, Lizhong;Ma, Siqi;Tang, Ning;Li, Xu;Xie, Yongjun;Xiang, Denghao;Fu, Jie;Shen, Jianqiang;Yang, Jun;Tu, Haifu;Li, Xianghua;Hu, Honghong;Xiong, Lizhong;Tang, Ning;Ma, Siqi;Shen, Jianqiang

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关键词： ABA signaling; transcriptional regulation; chromatin remodeling; histone monoubiquitination; rice

期刊名称：MOLECULAR PLANT （ 影响因子：13.164； 五年影响因子：16.357 ）

ISSN： 1674-2052

年卷期： 2019 年 12 卷 2 期

页码：

收录情况： SCI

摘要： Histone H2B monoubiquitination (H2Bub1) plays important roles in several physiological and developmental processes, but its roles in the regulation of plant stress responses remain elusive. Here, we report that H2Bub1 is crucially involved in abscisic acid (ABA) signaling and drought response in rice. We found that rice HISTONE MONOUBIQUITINATION2 (OsHUB2), an E3 ligase for H2Bub1, interacted with OsbZIP46, a key transcription factor regulating ABA signaling and drought response in rice. Genetic analyses suggest that OsHUB2, upregulated by drought and ABA, positively modulates ABA sensitivity and drought resistance. The H2Bub1 levels were increased in the target genes of OsbZIP46 under the drought stress and ABA treatments, which were positively correlated with their increased expression levels. Interestingly, MODD, a reported suppressor of ABA signaling and drought resistance by mediating OsbZIP46 deactivation and degradation, could reduce the H2Bub1 levels in the target genes of OsbZIP46 by recruiting a putative deubiquitinase OsOTLD1. Suppression of OsOTLD1 in vivo resulted in increased H2Bub1 levels and expression of OsbZIP46 target genes. Collectively, these findings established an elaborate mechanism of histone monoubiquitination in the fine-turning of ABA signaling and drought response by balancing H2Bub1 deposition and removal.

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