Simultaneous determination and dissipation behaviour of thifluzamide and difenoconazole in grapes using a QuEChERS method with ultra high-performance liquid chromatography and tandem mass spectrometry

文献类型： 外文期刊

第一作者： Liu, Xingang

作者： Liu, Xingang;Dong, Fengshou;Xu, Jun;Wu, Xiaohu;Zheng, Yongquan;Yu, Yang;Lin, Jun;Zheng, Yunxi

作者机构：

关键词： Difenoconazole; dissipation; grapes; LCMS/MS; QuEChERS; recoveries; thifluzamide

期刊名称：INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY （ 影响因子：2.826； 五年影响因子：2.215 ）

ISSN： 0306-7319

年卷期： 2019 年 99 卷 2 期

页码：

收录情况： SCI

摘要： In this study, a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method was used for the simultaneous determination of thifluzamide and difenoconazole in grapes by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) using a Waters Acquity UHPLC BEH C18 column. To compare the effects of different sorbents for thifluzamide and difenoconazole in grapes, samples were extracted with acetonitrile and cleaned up using five different types of sorbents at the same concentration level (0.1 mg/kg). The method was validated at three fortification concentrations (0.05, 0.1, 0.5 mg/kg) with five replicates in each matrix using 40 mg of primary secondary amine (PSA) + 10 mg of graphitised carbon black (GCB) as clean-up sorbents. The recoveries were between 76.3 and 109.3%, and the RSDr (intra-day precision, n = 5) and RSDR (inter-day precision, n = 15) values ranged from 3.5 to 8.1% and 5.8 to 22.2%, respectively. The limits of quantification (LOQ) for thifluzamide and difenoconazole were 0.07 and 0.04 mg/kg, respectively. The method showed excellent linearity and reliability. The results demonstrated that the method was effective in detecting the two compounds. In this study, we also investigated the dissipation behaviours of thifluzamide and difenoconazole in grapes. The dissipations of thifluzamide and difenoconazole followed the first-order kinetics with the half-lives of 3.9-16.3 days.

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