Kisspeptin and its Effect on Mammalian Spermatogensis

文献类型： 外文期刊

第一作者： Feng, Tao

作者： Feng, Tao;Bai, Jia H.;Xu, Xiao L.;Liu, Yan

作者机构：

关键词： Kisspeptin; GPR54; testis; sperm; gonadotrophins; testosterone; mammal

期刊名称：CURRENT DRUG METABOLISM （ 影响因子：3.731； 五年影响因子：3.601 ）

ISSN： 1389-2002

年卷期： 2019 年 20 卷 1 期

页码：

收录情况： SCI

摘要： Background: Kisspeptin and its receptor, GPR54, are regarded as key regulators of and catalysts for male puberty onset, and also fundamental gatekeepers of spermatogenesis in mammals. Consequently, the loss function of kisspeptin or GPR54 leads to a symptom of Hypogonadotropic Hypogonadism (HH) in human and HH accompanied by lower gonadotrophic hormone levels, smaller testes, impaired spermatogenesis and abnormal sexual maturation in mice. Besides its well-recognized functions in hypothalamus before and during puberty, accumulating data strongly support kisspeptin production in testis, and participation in somatic and germ cell development and sperm functions as well. This review aims to summarize recent findings regarding kisspeptin activity in the testes and sperm function. Methods: We undertook a keyword search of peer-reviewed research literature including data from in vivo and in vitro studies in humans and genetically modified animal models to identify the roles of kisspeptins in male reproduction. Results: A plethora of studies detail the role of kisspeptins and GPR54 in mammalian spermatogenesis in vivo and in vitro. This review identified recent findings regarding the kisspeptin system in male gonads, and regulation of kisspeptin in testicular physiology and male reproductive defects and disorders. Conclusion: The findings of this review confirm the importance role of kisspeptins in male fertility. Understanding their biphasic roles in testis may help to consider kisspeptins as potential pharmacological targets for treating human infertility.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序