Theaflavin-3,3-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways
文献类型： 外文期刊
第一作者： Gao, Ying
作者： Gao, Ying;Yin, Junfeng;Tu, Youying;Chen, Yi Charlie
作者机构：
关键词： theaflavin-3; 3-digallate; apoptosis; death receptors; Chk2; cell cycle arrest; p27
期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）
ISSN： 1420-3049
年卷期： 2019 年 24 卷 4 期
页码：
收录情况： SCI
摘要： Theaflavin-3,3-digallate (TF3) is a unique polyphenol in black tea. Epidemiological studies have proved that black tea consumption decreases the incidence rate of ovarian cancer. Our former research demonstrated that TF3 inhibited human ovarian cancer cells. Nevertheless, the roles of checkpoint kinase 2 (Chk2) and p27 kip1 (p27) in TF3-mediated inhibition of human ovarian cancer cells have not yet been investigated. In the current study, TF3 enhanced the phosphorylation of Chk2 to modulate the ratio of pro/anti-apoptotic Bcl-2 family proteins to initiate intrinsic apoptosis in a p53-independent manner and increased the expression of death receptors to activate extrinsic apoptosis in OVCAR-3 human ovarian carcinoma cells. In addition, TF3 up-regulated the expression of p27 to induce G0/G1 cell cycle arrest in OVCAR-3 cells. Our study indicated that Chk2 and p27 were vital anticancer targets of TF3 and provided more evidence that TF3 might be a potent agent to be applied as adjuvant treatment for ovarian cancer.
分类号：
- 相关文献
作者其他论文 更多>>
-
Whole genome re-sequencing to reveal genetic diversity and to develop snp array in common tobacco
作者：Jiao, Fangchan;Wu, Xingfu;Song, Zhongbang;Chen, Xuejun;Li, Yongping;Li, Tianbao;Gao, Lifeng;Gao, Ying;Sun, Congwei
关键词：Genetic diversity; Genetic transmission; Genome re-sequencing;
Nicotiana tabacum ; SNP array Nt660YN -
Sustained-release effect of eggshell powder microcapsules on lavender essential oil
作者：Zhang, Ziwei;Gao, Ying;Huo, Jiaying;Li, Shugang;Liu, Yanlong;Dong, Shijian;Liu, Liya;Liu, Yanlong
关键词：Eggshell powder; Microcapsules; Lavender essential oil; Sustained-release characteristics; Antioxidant stability
-
Encapsulation of EGCG by whey protein isolate and (3-cyclodextrin nanocomplexes: A strategy to mask the bitter and astringent taste and increase the stability in beverages
作者：Xie, Hujun;Wang, Han;Huang, Min;Li, Hao;Jiao, Qingbo;Ren, Gerui;Gao, Ying;Cao, Qing-Qing;Xu, Yong-Quan;Xie, Hujun;Huang, Min;Ren, Gerui
关键词：Encapsulation; Sustained-release; EGCG; WPI; (3-CD; Bitter and astringent taste
-
Determination of potential α-glucosidase inhibitors in Jinxuan black tea based on bioaffinity ultrafiltration combined with UHPLC-Q-Exactive-MS
作者：Li, Guangneng;Zhang, Jianyong;Gao, Ying;Deng, Yuliang;Yin, Junfeng;Li, Guangneng;Niu, Debao;Cui, Hongchun
关键词：Black tea; alpha-Glucosidase; Inhibitor; Affinity ultrafiltration; Theasinensin A; Catechin; Inhibition mechanism
-
Quantitative descriptive analysis, non-targeted metabolomics and molecular docking reveal the dynamic aging and taste formation mechanism in raw Pu-erh tea during the storage
作者：Ma, Bingsong;Ma, Cunqiang;Chen, Xuan;Wang, Yuhua;Li, Xinghui;Ma, Bingsong;Li, Yifan;Yin, Junfeng;Zhou, Binxing
关键词：Stored tea; Taste compounds; Aging mechanism; Molecular docking; Kokumi
-
Enzyme-assisted dynamic extraction as a promising method to produce high-quality fresh tea juice from summer tea leaves
作者：Li, Yuan-Chao;Fu, Yan-Qing;Gao, Ying;Wang, Jie-Qiong;Chen, Jian-Xin;Xu, Yong-Quan;Li, Yuan-Chao;Jin, Shan;Xu, Yong-Quan;Liu, Yanglong
关键词：Abandon-plucked tea; Dynamic extraction; Enzyme treatment; Green tea juice
-
Improving the Surface Color and Delaying Softening of Peach by Minimizing the Harmful Effects of Ethylene in the Package
作者：Zhou, Hongsheng;Zhang, Yingtong;Ling, Jun;Li, Pengxia;Zhou, Hongsheng;Zhao, Jing;Gao, Ying;Zhou, Qian;Zhou, Hongsheng;Ma, Siyu;Huang, Wen
关键词：peach; modified atmosphere packaging; ethylene absorbent; firmness; anthocyanin
