The effects of dietary astaxanthin on intestinal health of juvenile tiger puffer Takifugu rubripes in terms of antioxidative status, inflammatory response and microbiota

文献类型： 外文期刊

第一作者： Ou, Weihao

作者： Ou, Weihao;Yu, Guijuan;Mai, Kangsen;Zhang, Yanjiao;Liao, Zhangbin;Xu, Houguo;Liang, Mengqing;Xu, Houguo;Liang, Mengqing;Mai, Kangsen;Zhang, Yanjiao

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关键词： antioxidant; astaxanthin; inflammation; intestine; microbiota; Takifugu rubripes

期刊名称：AQUACULTURE NUTRITION （ 影响因子：3.497； 五年影响因子：3.78 ）

ISSN： 1353-5773

年卷期： 2019 年 25 卷 2 期

页码：

收录情况： SCI

摘要： A 74-day feeding trial was conducted to evaluate the effects of dietary astaxanthin (ASTX) on antioxidative status, inflammatory response and microbiota in the intestine of tiger puffer. Four diets differed only in ASTX content, that is, 0 (Control), 50 (ASTX50), 100 (ASTX100) and 500 (ASTX500) mg/kg. Compared with Control, ASTX50 and ASTX100 significantly reduced the malondialdehyde content and spared the activities of antioxidative enzymes in hindgut; however, ASTX500 had higher activity and gene expression of antioxidative enzymes. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) signalling were probably involved in the transcriptional regulation of antioxidative enzymes by dietary ASTX. Compared with Control and ASTX500, ASTX50 and ASTX100 decreased the leucocyte infiltration in the lamina propria of hindgut and down-regulated the gene expression of tumour necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8). ASTX markedly affected the overall structure of intestinal microbiota. The relative abundance of Arcobacter, which has harmful properties, was the lowest in ASTX100 but the highest in ASTX500. In conclusion, dietary ASTX at 50 or 100 mg/kg improved the antioxidative status, alleviated the inflammation and favourably modulated the microbiota in tiger puffer intestine, but excess ASTX exerted contrary effects.

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