Determination of pesticides and Pharmaceuticals from Fish Cultivation Water by parallel solid-phase extraction (SPE) and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)

文献类型： 外文期刊

第一作者： Gao, Lei

作者： Gao, Lei;Qin, Dongli;Huang, Xiaoli;Wu, Song;Chen, Zhongxiang;Tang, Shizhan;Wang, Peng

作者机构：

关键词： Liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS); parallel solid-phase extraction (SPE); pesticides; pharmaceuticals

期刊名称：ANALYTICAL LETTERS （ 影响因子：2.329； 五年影响因子：1.738 ）

ISSN： 0003-2719

年卷期： 2019 年 52 卷 6 期

页码：

收录情况： SCI

摘要： A screening method for multiple classes of pesticides and pharmaceuticals from fish cultivation water was established using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Parallel solid-phase extraction (SPE) with different adsorbents was selected for extracting and purifying analytes with different properties. This method allowed for efficient and economical screening of a virtually unlimited number of compounds without reference standards. In order to evaluate the feasibility of this method, 25 pesticides and pharmaceuticals with different properties were selected. The screening detection limit of this method was 0.015 mu g L-1, which was lower than the maximum residue limits. This value showed that the method was suitable for screening organic contaminants in fish cultivation water. In a simulation experiment, the organic contaminants with high intensity (atrazine and carbendazim) were identified by retention time, accurate mass, isotopic pattern, and the main fragment ions. Moreover, the information about the organic contaminants and MS2 spectra was added into a database. Since the QTOF-MS data were traceable, they were saved and could be reexamined for compounds that previously were unexpected. This method provides insight into the screening and identification of organic contaminants in water samples, as well as risk assessment and fishery accident identification.

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