Toxicity of ZnO nanoparticles (NPs) to THP-1 macrophages: interactions with saturated or unsaturated free fatty acids

文献类型： 外文期刊

第一作者： Jiang, Mengdie

作者： Jiang, Mengdie;Wu, Bihan;Liu, Liangliang;Cao, Yi;Jiang, Mengdie;Wu, Bihan;Ding, Yanhuai;Xie, Yixi;Cao, Yi;Sun, Yongbing

作者机构：

关键词： ZnO nanoparticles (NPs); THP-1 macrophages; free fatty acids (FFA); inflammation; endoplasmic reticulum (ER) stress

期刊名称：TOXICOLOGY MECHANISMS AND METHODS （ 影响因子：2.987； 五年影响因子：2.78 ）

ISSN： 1537-6516

年卷期： 2019 年 29 卷 4 期

页码：

收录情况： SCI

摘要： In a biological microenvironment, free fatty acids (FFA) as ubiquitous biological molecules might interact with nanoparticles (NPs) and consequently change the toxicological responses. However, whether the chemical structures of FFA could influence their interactions with NPs remain unknown. This study investigated the interactions between ZnO NPs and saturated or unsaturated FFA (complexed to BSA), namely stearic acid (SA, C18:0), oleic acid (OA, C18:1), and alpha-linolenic acid (ALA, C18:3). It was shown that BSA, SA, OA, and ALA increased the atomic force microscope (AFM) heights as well the polydispersity index (PDI) of ZnO NPs. BSA modestly protected THP-1 macrophages from ZnO NP exposure, whereas OA and ALA led to relatively less cyto-protective effects of BSA. Moreover, only co-exposure to ZnO NPs and SA significantly promoted the release of interleukin-8. BSA, SA, OA, and ALA equally changed intracellular ROS and Zn ions associated with ZnO exposure, but co-exposure to ZnO NPs and OA/ALA particularly activated the expression of endoplasmic reticulum stress-apoptosis genes. In combination, these results showed that FFA could influence the colloidal aspects and toxicological signaling pathway of ZnO NPs, which is dependent on the number of unsaturated bonds of FFA.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序