Study on Antidepressant Activity of Pseudo-Ginsenoside HQ on Depression-Like Behavior in Mice

文献类型： 外文期刊

第一作者： Chen, Li-xue

作者： Chen, Li-xue;Shao, Zi-jun;Li, Shan-shan;Qi, Yu-li;Gao, Kun;Liu, Song-xin;Sun, Yin-shi;Chen, Li-xue;Shao, Zi-jun;Qi, Yu-li;Gao, Kun;Liu, Song-xin;Sun, Yin-shi;Qi, Zeng;Li, Zhuo;Li, Ping-ya

作者机构：

关键词： ginsenoside Rh-2; (24R)-pseudo-ginsenoside HQ; (24S)-pseudo-ginsenoside HQ; LPS-induced depression

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2019 年 24 卷 5 期

页码：

收录情况： SCI

摘要： Suppressive effects of ginsenoside Rh-2 (Rh-2), (24R)-pseudo-ginsenoside HQ (R-PHQ), and (24S)-pseudo-ginsenoside HQ (S-PHQ) against lipopolysaccharide (LPS)-induced depression-like behavior were evaluated using the forced swimming test (FST) and tail suspension test (TST) in mice. Pretreatment with Rh-2, R-PHQ, and S-PHQ significantly decreased immobility time in FST and TST with clear dose-dependence, and significantly downregulated levels of serum tumor necrosis factor-alpha and interleukin-6, and upregulated superoxide dismutase activity in the hippocampus of LPS-challenged mice. Furthermore, R-PHQ and S-PHQ significantly increased the expression of the brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB), sirtuin type 1 (Sirt1), and nuclear-related factor 2, and inhibited the phosphorylation of inhibitor of kappa B-alpha and nuclear factor-kappa B (NF-kappa B) in the hippocampus of LPS-challenged mice. Additionally, the antidepressant-like effect of R-PHQ was found related to the dopaminergic (DA), gamma-aminobutyric acid (GABA)ergic, and noradrenaline systems, while the antidepressive effect of S-PHQ was involved in the DA and GABAergic systems. Taken together, these results suggested that Rh-2, R-PHQ, and S-PHQ produced significant antidepressant-like effects, which may be related to the BDNF/TrkB and Sirt1/NF-kappa B signaling pathways.

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