文献类型： 外文期刊
第一作者： Zhang, Jun
作者： Zhang, Jun;Liu, Sha-Sha;Yuan, Wei-Yu;Luo, Du-Qiang;Zhao, You-Xing;Wei, Jing-Jing
作者机构：
关键词： Isaria fumosorosea; carotane sesquiterpenes; cytotoxicity
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）
ISSN： 1028-6020
年卷期： 2019 年 21 卷 3 期
页码：
收录情况： SCI
摘要： Two new carotane-type sesquiterpenes named trichocaranes E (1) and F (2), along with two known ones CAF-603 (3) and trichocarane C (4), were isolated from cultures of the insect pathogenic fungus Isaria fumosorosea. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-3 showed potent cytotoxic activities against six tumor cell lines MDA, MCF-7, SKOV-3, Hela, A549, HepG2 with IC50 values in a concentration range of 0.1-6.0 mu g/ml. [GRAPHICS]
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