Carotane-type sesquiterpenes from cultures of the insect pathogenic fungus Isaria fumosorosea

文献类型: 外文期刊

第一作者: Zhang, Jun

作者: Zhang, Jun;Liu, Sha-Sha;Yuan, Wei-Yu;Luo, Du-Qiang;Zhao, You-Xing;Wei, Jing-Jing

作者机构:

关键词: Isaria fumosorosea; carotane sesquiterpenes; cytotoxicity

期刊名称:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH ( 影响因子:1.569; 五年影响因子:1.598 )

ISSN: 1028-6020

年卷期: 2019 年 21 卷 3 期

页码:

收录情况: SCI

摘要: Two new carotane-type sesquiterpenes named trichocaranes E (1) and F (2), along with two known ones CAF-603 (3) and trichocarane C (4), were isolated from cultures of the insect pathogenic fungus Isaria fumosorosea. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-3 showed potent cytotoxic activities against six tumor cell lines MDA, MCF-7, SKOV-3, Hela, A549, HepG2 with IC50 values in a concentration range of 0.1-6.0 mu g/ml. [GRAPHICS]

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