Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas

文献类型： 外文期刊

第一作者： Rosani, Umberto

作者： Rosani, Umberto;Venier, Paola;Young, Tim;Alfaro, Andrea C.;Bai, Chang-Ming

作者机构：

关键词： OsHV-1; Crassostrea gigas; omics

期刊名称：EVOLUTIONARY BIOINFORMATICS （ 影响因子：1.625； 五年影响因子：2.38 ）

ISSN： 1176-9343

年卷期： 2019 年 15 卷

页码：

收录情况： SCI

摘要： Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the currently used "omics" technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of viral DNA in the host tissues has greatly advanced the knowledge of genes and pathways mostly contributing to host defense responses, expression profiles of annotated and unknown OsHV-1 open reading frames (ORFs), and viral genome variability. In addition to dual RNA-seq, proteomics and metabolomics analyses have the potential to add complementary information, needed to understand how a malacoherpesvirus can redirect and exploit the vital processes of its host. This review explores our current knowledge of "omics" technologies in the study of host-pathogen interactions and highlights relevant applications of these fields of expertise to the complex case of C gigas infections by OsHV-1, which currently threaten the mollusk production sector worldwide.

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