Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus

文献类型： 外文期刊

第一作者： Li, Xiu-Mei

作者： Li, Xiu-Mei;Wang, Jin-Quan;Yang, Pei-Long;Li, Xiu-Mei;Yang, Pei-Long;Li, Zhong-Yuan;Wang, Ya-Dong;Li, Zhong-Yuan;Wang, Ya-Dong

作者机构：

关键词： quercetin; Aspergillus flavus; transcriptome; RNA-seq; aflatoxin

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

ISSN： 2072-6651

年卷期： 2019 年 11 卷 3 期

页码：

收录情况： SCI

摘要： In this work of quercetin's anti-proliferation action on A. flavus, we revealed that quercetin can effectively hamper the proliferation of A. flavus in dose-effect and time-effect relationships. We tested whether quercetin induced apoptosis in A. flavus via various detection methods, such as phosphatidylserine externalization and Hoechst 33342 staining. The results showed that quercetin had no effect on phosphatidylserine externalization and cell nucleus in A. flavus. Simultaneously, quercetin reduced the levels of reactive oxygen species (ROS). For a better understanding of the molecular mechanism of the A. flavus response to quercetin, the RNA-Seq was used to explore the transcriptomic profiles of A. flavus. According to transcriptome sequencing data, quercetin inhibits the proliferation and aflatoxin biosynthesis by regulating the expression of development-related genes and aflatoxin production-related genes. These results will provide some theoretical basis for quercetin as an anti-mildew agent resource.

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