Synthesis and Bio-Evaluation of Natural Butenolides-Acrylate Conjugates

文献类型： 外文期刊

第一作者： Bao, Longzhu

作者： Bao, Longzhu;Wang, Shuangshuang;Song, Di;Wang, Jingjing;Cao, Xiufang;Ke, Shaoyong

作者机构：

关键词： 3-aryl-4-hydroxy-2(5H)-furanone; butenolides; acrylate; antifungal activity; natural product

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2019 年 24 卷 7 期

页码：

收录情况： SCI

摘要： A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by H-1-NMR, C-13-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg center dot L-1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

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