An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A-D and their derivatives

文献类型： 外文期刊

第一作者： Ke, Shaoyong

作者： Ke, Shaoyong;Zhang, Zhigang;Shi, Liqiao;Liu, Manli;Fang, Wei;Zhang, Yani;Wu, Zhaoyuan;Wan, Zhongyi;Long, Tong;Wang, Kaimei

作者机构：

期刊名称：ORGANIC & BIOMOLECULAR CHEMISTRY （ 影响因子：3.876； 五年影响因子：3.397 ）

ISSN： 1477-0520

年卷期： 2019 年 17 卷 14 期

页码：

收录情况： SCI

摘要： Oxazoles are an important class of biologically active metabolites from nature, and exhibit broad biological activities as the lead for drug discovery. Hinduchelins are a class of unusual natural products with an oxazole unit, isolated from Streptoalloteichus hindustanus, and with a potential iron-chelating ability. These compounds are the first identified naturally occurring unusual oxazole derivatives to possess a catechol unit. However, some of these compounds are not abundant in nature, and thus, the efficient syntheses of these compounds are advantageous in exploring their potential applications. This paper reports the efficient synthesis and bio-evaluation of hinduchelins A-D and their derivatives with convenient procedures and high yields.

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