Immunogenicity and cross-protective efficacy of double-mutant Streptococcus suis Delta SspepO/Delta SspspC serotypes 2 and 7

文献类型： 外文期刊

第一作者： Hu, Jin

作者： Hu, Jin;Xu, Jiali;Liu, Feng;Tan, Chen;Chen, Huanchun;Bei, Weicheng;Hu, Jin;Xu, Jiali;Liu, Feng;Tan, Chen;Chen, Huanchun;Bei, Weicheng;Xu, Jiali;Liu, Feng;Tan, Chen;Chen, Huanchun;Bei, Weicheng;Yuan, Fangyan

作者机构：

关键词： Streptococcus suis; Delta SspepO/Delta SspspC; Vaccine; Immunogenicity; Cross-protection

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2019 年 37 卷 16 期

页码：

收录情况： SCI

摘要： Streptococcus suis serotype 2 (S. suis 2) is a major pathogen causing streptococcosis in swine, resulting in significant losses in swine breeding worldwide. We previously reported that the non-antibiotic-resistant double-mutant strain Delta SspepO/Delta SspspC can be used as a live vaccine, providing effective protection against S. suis 2 infections in mice. This study aimed to understand the characteristics of streptococcosis and develop vaccine candidates for immunization. Intramuscular injection of live S. suis Delta SspepO/Delta SspspC in pigs induced discernable antibody production and provided cross-protection against challenges by a type 2 strain (100% protection) and a type 7 strain (60% protection). Protection was evaluated via clinical, bacteriological, serological, and post-mortem examinations. Furthermore, vaccination induced the production of opsonizing antibodies against serotypes 2 and 7. Analysis of IgG subclasses (IgG1 and IgG2a) revealed that both Th1 and Th2 responses were induced by S. suis Delta SspepO/Delta SspspC, although the IgG2a (Thl) response predominated over the IgG1 (Th2) response. This study is the first, to our knowledge, to establish a live vaccine candidate to protect against two major S. suis serotypes. Further studies are required to assess these candidate vaccines and examine their feasibility in providing cross-protection against S. suis. (C) 2019 Elsevier Ltd. All rights reserved.

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