Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp.

文献类型： 外文期刊

第一作者： Yang, Cheng Long

作者： Yang, Cheng Long;Wu, Hui Min;Liu, Cheng Li;Zhang, Xuan;Jiao, Rui Hua;Tan, Ren Xiang;Ge, Hui Ming;Tan, Ren Xiang;Guo, Zhi Kai;Chen, Yu;Liu, Fang;Liang, Yong

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2019 年 82 卷 4 期

页码：

收录情况： SCI

摘要： Six novel aromatic polyketide dimers, bialternacins A-F (1-6), were isolated from a plant endophytic Alternaria sp. The structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. Compounds 1, 2, 5, and 6 were characterized as four pairs of racemic mixtures. Compound (+)-5 was demonstrated to show acetylcholinesterase inhibitory activity with an IC50 value of 15.5 mu M. A putative biosynthetic pathway for these compounds was proposed.

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