Melatonin alleviates the deterioration of oocytes from mice subjected to repeated superovulation

文献类型： 外文期刊

第一作者： Xiao, Peng

作者： Xiao, Peng;Nie, Junyu;Wang, Xuefang;Lu, Kehuan;Lu, Shengsheng;Liang, Xingwei;Xiao, Peng;Nie, Junyu;Wang, Xuefang;Lu, Kehuan;Lu, Shengsheng;Liang, Xingwei;Xiao, Peng;Xiao, Peng

作者机构：

关键词： meiosis; melatonin; mouse; oocyte; repeated superovulation

期刊名称：JOURNAL OF CELLULAR PHYSIOLOGY （ 影响因子：6.384； 五年影响因子：5.987 ）

ISSN： 0021-9541

年卷期： 2019 年 234 卷 8 期

页码：

收录情况： SCI

摘要： Induction of repeated superovulation with exogenous hormones is widely used in assisted reproductive technology (ART). Though it is generally safe, emerging evidence has indicated that repeated superovulation may compromise oocyte quality. However, few studies have explored how to ameliorate such impairment. Because melatonin has beneficial influences on oocytes in various detrimental environments, we aimed to explore whether melatonin could protect mouse oocytes after repeated superovulation. We found that repeated superovulation markedly reduced meiotic maturation and disrupted spindle organization and chromosome alignment. Furthermore, we observed reduced mitochondrial content and enhanced early apoptosis in oocytes from mice subjected to repeated superovulation. In addition, 5-methylcytosine (5mc) fluorescence intensity was lower in oocytes from experimental mice than in those from control mice, indicating that repeated superovulation disrupts genomic DNA methylation, and elevations in reactive oxygen species levels indicated that repeated superovulation also induces oxidative stress. Conversely, melatonin administration improved oocyte maturation and attenuated the observed defects. Interestingly, supplementation with melatonin during in vitro maturation had the same protective effects on oocytes as in vivo melatonin administration. In summary, our results show that melatonin can improve oocyte quality after repeated superovulation and thus provide a potential strategy to improve ART efficiency.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Characteristic volatile flavors of high-oleic peanut oil and normal peanut oil

    作者：Huang, Fengzhen;Liu, Ao;Fang, Mengxue;Wang, Du;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Huang, Fengzhen;Liu, Ao;Fang, Mengxue;Wang, Du;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Huang, Fengzhen;Liu, Ao;Fang, Mengxue;Wang, Du;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Huang, Fengzhen;Liu, Ao;Fang, Mengxue;Wang, Du;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Zhang, Liangxiao;Zhang, Liangxiao;Li, Peiwu

    关键词：High-oleic peanut oil; HS-SPME-GC-MS; Volatile compounds; Sensory evaluation; Flavor stability

  • CX43 and oxidative stress are the targets of BCB staining to predict the developmental potential of buffalo oocytes

    作者：Li, MengQi;Yang, ChunYan;Duan, AnQin;Xiao, Peng;Lu, XingRong;Ma, XiaoYa;Xu, YuanYuan;Zheng, Wei;Feng, Chao;Mo, Xia;Huang, ChenQian;Huang, LiQing;Shang, JiangHua;Zheng, HaiYing;Li, MengQi;Xiao, Peng;Yang, ChunYan;Duan, AnQin;Lu, XingRong;Ma, XiaoYa;Zheng, Wei;Feng, Chao;Mo, Xia;Huang, ChenQian;Shang, JiangHua;Zheng, HaiYing;Xiao, Peng

    关键词：BCB staining; buffalo oocyte; developmental potential prediction; gap junction; oxidative stress

  • Prevention of Cadmium Contamination by Microbial Inoculant and Its Potential Mechanism

    作者：Xu, Ximei;Xu, Baocheng;Xu, Ximei;Yue, Xiaofeng;Wang, Du;Fang, Mengxue;Yu, Li;Ma, Fei;Yin, Nanri;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Xu, Ximei;Yue, Xiaofeng;Wang, Du;Fang, Mengxue;Yu, Li;Ma, Fei;Yin, Nanri;Wang, Xuefang;Xu, Baocheng;Zhang, Liangxiao;Li, Peiwu;Xu, Ximei;Yue, Xiaofeng;Wang, Du;Fang, Mengxue;Yu, Li;Ma, Fei;Yin, Nanri;Wang, Xuefang;Xu, Baocheng;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Li, Peiwu;Li, Peiwu

    关键词：ARC microbial inoculant; peanut; cadmium; morphological distribution

  • Nutrients in rice bran oil and their nutritional functions: a review

    作者：Tian, Xuan;Wang, Xueyan;Fang, Mengxue;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Tian, Xuan;Wang, Xueyan;Fang, Mengxue;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Tian, Xuan;Wang, Xueyan;Fang, Mengxue;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Tian, Xuan;Wang, Xueyan;Fang, Mengxue;Yu, Li;Ma, Fei;Wang, Xuefang;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Li, Peiwu

    关键词：Bioactive components; gamma-oryzanol; nutritional functions; rice bran oil

  • A study of the pesticide residues in rapeseeds in China: Levels, distribution and health risk assessment

    作者：Guo, Qi;Yue, Xiaofeng;Qi, Xin;Wang, Xuefang;Hu, Xiaofeng;Ma, Fei;Zhang, Liangxiao;Li, Peiwu;Yu, Li;Zhang, Liangxiao;Li, Peiwu;Li, Peiwu;Feng, Xinyao;Yu, Li

    关键词：Pesticide residues; Rapeseed; China; Risk assessment

  • Geographical origin identification of camellia oil based on fatty acid profiles combined with one-class classification

    作者：Dou, Xinjing;Wang, Xuefang;Ma, Fei;Yu, Li;Mao, Jin;Jiang, Jun;Zhang, Liangxiao;Li, Peiwu;Zhang, Liangxiao;Mao, Jin;Zhang, Liangxiao;Li, Peiwu;Li, Peiwu

    关键词：Camellia oil; Fatty acid profiles; Geographical origin traceability; One-class classification

  • Follicular Atresia in Buffalo: Cocaine- and Amphetamine-Regulated Transcript (CART) and the Underlying Mechanisms

    作者：Yang, Chunyan;Zheng, Haiying;Amin, Ahmed;Duan, Anqin;Li, Lingyu;Xiao, Peng;Li, Mengqi;Shang, Jianghua;Yang, Chunyan;Zheng, Haiying;Amin, Ahmed;Duan, Anqin;Xiao, Peng;Li, Mengqi;Shang, Jianghua;Amin, Ahmed;Faheem, Marwa S.

    关键词：follicular atresia; buffalo; granulosa cells; apoptosis; cocaine- and amphetamine-regulated transcript (CART); AKT/GSK3 beta/beta-catenin

微信小程序