Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells

文献类型： 外文期刊

第一作者： Hu, Tingyan

作者： Hu, Tingyan;Linghu, Kegang;Wang, Y. T.;Huang, Siqi;Li, Defang;Battino, Maurizio;Georgiev, Milen I.;Zengin, Gokhan;Deng, Yun;Cao, Hui;Cao, Hui

作者机构：

关键词： Flaxseed; MCF-7 cells; Apoptosis; ROS; Mitochondrial membrane potential; Dietary supplement

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2019 年 127 卷

页码：

收录情况： SCI

摘要： Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which was also shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.

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