Effect of dynamic high pressure microfluidization on structure and stability of pluronic F127 modified liposomes

文献类型： 外文期刊

第一作者： Li, Ziling

作者： Li, Ziling;Peng, Shengfeng;Chen, Xing;Zhu, Yuqing;Zou, Liqiang;Liu, Wei;Liu, Chengmei;Li, Ziling;Zhou, Wei

作者机构：

关键词： Pluronic F127; liposomes; dynamic high pressure microfluidization; interaction; stability

期刊名称：JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY （ 影响因子：2.262； 五年影响因子：2.064 ）

ISSN： 0193-2691

年卷期： 2019 年 40 卷 7 期

页码：

收录情况： SCI

摘要： Pluronics modified liposomes have been prepared and shown to enhance stability of liposomes in our previous reports. In this study, we intended to evaluate the effect of dynamic high pressure microfluidization (DHPM) on the structure and stability of pluronic F127 modified liposomes. The results indicated that the particle size of F127 modified liposomes was decreased from 1180.6 nm to 73.5 nm after DHPM treatment. Meanwhile, the morphology was changed from irregularly multilamellar vesicle to spherically unilamellar structure. Structural characteristics were examined by fourier transformed infrared spectrometer, differential scanning calorimetry and X-ray powder diffraction. The subtle difference of structure might be attributed to the incorporation of PPO chains into the bilayer caused by DHPM treatment. Stability studies indicated that DHPM treatment could enhance the storage and membrane stability of F127 modified liposomes. This study may provide more insight to understand the effect of preparation method on the structure and stability of F127 modified liposomes. [GRAPHICS] .

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