Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion-fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress
文献类型： 外文期刊
第一作者： Ren, Shanhui
作者： Ren, Shanhui;Rehman, Zaib Ur;Shi, Mengyu;Liu, Panrao;Qu, Yurong;Meng, Chunchun;Sun, Yingjie;Ding, Chan;Yang, Bin;Yin, Yuncong;Yang, Zengqi;Gao, Xiaolong;Ding, Chan
作者机构：
期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）
ISSN： 0928-4249
年卷期： 2019 年 50 卷
页码：
收录情况： SCI
摘要： The fusogenically activated F and HN proteins of virulent NDV induce complete autophagic flux in DF-1 and A549 cells. However, the effect of both glycoproteins on mitochondria remains elusive. Here, we found that F and HN cooperation increases mitochondrial biogenesis but does not cause the mitochondria damage. We observed that both glycoproteins change the morphological characteristics and spatial distribution of intracellular mitochondria. F and HN cooperate cooperatively to induce ER stress and UPRmt. Our preliminary data suggested that F and HN cooperatively disturb mitochondrial fusion-fission homeostasis to enhance mitochondrial biogenesis, and eventually meet the energy demand of syncytium formation.
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