Molecular chaperone-like properties of sodium caseinate to suppress the pressure-induced aggregation of -lactoglobulin

文献类型： 外文期刊

第一作者： He, Jin-Song

作者： He, Jin-Song;Gao, Qing;Mu, Tai-Hua;Azuma, Norihiro

作者机构：

关键词： High pressure; sodium caseinate; molecular chaperone; -lactoglobulin; aggregation

期刊名称：HIGH PRESSURE RESEARCH （ 影响因子：1.431； 五年影响因子：2.243 ）

ISSN： 0895-7959

年卷期： 2019 年 39 卷 2 期

页码：

收录情况： SCI

摘要： The objective of this study was to determine whether sodium caseinate can inhibit the aggregation of whey protein induced by pressure treatment. Solutions of -lactoglobulin (-Lg, 0.2%, w/v) and mixtures containing 0.2% (w/v) -Lg and 0-0.5% (w/v) sodium caseinate (NaCas) were pressurized at 400-800MPa. NaCas suppressed the aggregation of -Lg induced by pressure treatment, and this function was dependent on the concentration of NaCas. Furthermore, NaCas altered the aggregation process of -Lg by suppressing the transition of the aggregate from the soluble phase to the insoluble phase and, as a result, the fraction of insoluble aggregates was decreased. During this process, NaCas formed stable complexes with the denatured -Lg, and the formation of complexes prevented further aggregation of -Lg. These results indicate that NaCas exhibits a chaperone-like activity under high pressure.

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