Antibacterial bibenzyl derivatives from the tubers of Bletilla striata

文献类型： 外文期刊

第一作者： Jiang, Sai

作者： Jiang, Sai;Wan, Ke;Lou, Hua-Yong;Yi, Ping;Zhang, Ni;Zhou, Mei;Pan, Wei-Dong;Song, Zhi-Qin;Wu, Ming-Kai;Jiang, Sai;Wang, Wei

作者机构：

关键词： Bletilla striata; Orchidaceae; Bibenzyl derivatives; Antibacterial activities; Minimum inhibitory concentration (MIC)

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）

ISSN： 0031-9422

年卷期： 2019 年 162 卷

页码：

收录情况： SCI

摘要： Ten previously undescribed bibenzyl derivatives (bletistrins A-J), including 5 that have hydroxyl-substituted chiral centres on the aliphatic bibenzyl bridge, along with twelve known bibenzyl derivatives, were isolated from the rhizomes of Bletilla striata. The structures of bletistrins A-J were primarily elucidated on the basis of their 1D and 2D NMR spectroscopic data. The absolute configurations of bletistrins A, D, F, H and I were determined by electronic circular dichroism (ECD) spectroscopic analysis and optical rotation value. Most of the isolated compounds were evaluated for their antibacterial activities against 3 g-positive bacterial strains and 1 g-negative bacterial strain. Bletistrins F, G, and J, bulbocol, shanciguol and shancigusin B showed inhibitory activities, with MICs of (3-28 mu g/mL) against S. aureus ATCC 6538.

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