New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398
文献类型： 外文期刊
第一作者： Sun, Chunxiao
作者： Sun, Chunxiao;Ge, Xueping;Mudassir, Shah;Zhou, Luning;Che, Qian;Zhang, Guojian;Gu, Qianqun;Zhu, Tianjiao;Li, Dehai;Yu, Guihong;Zhang, Guojian;Li, Dehai;Peng, Jixing;Peng, Jixing;Li, Dehai
作者机构：
关键词： Chaetomium globosum; azaphilone alkaloids; cytotoxicity; deep-sea-derived fungus
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN： 1660-3397
年卷期： 2019 年 17 卷 5 期
页码：
收录情况： SCI
摘要： Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A-C (1-3), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. N-glutarylchaetoviridins A-C (1-3) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (6-10) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines.
分类号：
- 相关文献
作者其他论文 更多>>
-
Metabolic transformation of paralytic shellfish toxins in the mussel Mytilus galloprovincialis under different exposure modes
作者：Zheng, Guanchao;Che, Hanyu;Wu, Haiyan;Deng, Yuxiang;Guo, Mengmeng;Peng, Jixing;Geng, Qianqian;Tan, Zhijun;Tan, Zhijun;Tan, Zhijun
关键词：Paralytic shellfish toxins; Mytilus galloprovincialis; Gymnodinium catenatum; Epimerization conversion
-
Seasonal and inter-species variations in nutrient components and taste characteristics of farmed scallops from Northern China
作者：Lin, Yichen;Peng, Jixing;Zhao, Xinnan;Song, Dongru;Tan, Zhijun;Geng, Shichang;Tan, Zhijun
关键词：Farmed scallops; Seasonal variations; Interspecies difference; Nutrient and flavor composition; Quality comprehensive assessment
-
Fatty acids and lipids in sea cucumber from the Rongcheng Sanggou Bay, China: Variation characteristics and diversity profile of farming patterns and harvest seasons
作者：Zhao, Xinnan;Lin, Yichen;Huo, Shanqin;Wu, Haiyan;Guo, Mengmeng;Tan, Zhijun;Peng, Jixing;Tan, Zhijun
关键词：Apostichopus japonicus; Fatty acids; Lipidomic; Phospholipids; UPLC; HRMS
-
Comprehensive quality evaluation for oysters of geographical indication from Rushan in China: Characteristic profile of nutrition and flavor components
作者：Huo, Shanqin;Peng, Jixing;Zhao, Xinnan;Lin, Yichen;Wu, Haiyan;Zheng, Guanchao;Geng, Qianqian;Guo, Mengmeng;Tan, Zhijun;Huo, Shanqin;Tan, Zhijun
关键词：Crassostrea gigas; Nutrition quality; Flavor components; Comprehensive evaluation
-
3-Fucosyllactose Prevents Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota-Derived Pantothenate in Mice
作者：Liu, Bei;He, Ningning;Li, Hui;Yang, Zizhen;Wu, Xiaoyu;Zhang, Haoyan;Zhang, Ziheng;Zhang, Zishuai;Li, Shangyong;Lin, Yichen;Peng, Jixing;Tian, Yu;Wu, Zhinan;Zou, Yuanqiang;Tian, Yu;Wu, Zhinan
关键词：nonalcoholic fatty liver disease; gut microbiota; pantothenate; fatty acid biosynthesis; noninvasivediagnostic biomarker
-
Effects of methoxy groups and carbon-carbon double bonds in phenolic acids on the physicochemical characteristics and digestibility of cassava starch
作者：Lv, Guangjia;Zhang, Xuan;Xu, Fei;Zhu, Kexue;Zhang, Yutong;Zhang, Yanjun;Lv, Guangjia;Qin, Yajuan;Zhang, Xuan;Xu, Fei;Zhu, Kexue;Zhang, Yutong;Zhang, Yanjun;Lv, Guangjia;Li, Dehai;Bao, Yihong;Qin, Yajuan;Bao, Yihong;Qin, Yajuan;Zhang, Yutong
关键词：Methoxy groups; Carbon-carbon double bonds; Phenolic acids; Nonpolar; Weakly polar; In vitro starch digestion
-
Pyridine Derivatives and Furan Derivatives Identified From the Medicinal Mushroom Irpex lacteus SY1002
作者：Yu, Guihong;Shang, Zhaomeng;Li, Wanting;Mo, Xuhua;Yang, Song;Tan, Lingling;Yu, Guihong;Shang, Zhaomeng;Li, Wanting;Mo, Xuhua;Yang, Song;Tan, Lingling;Yu, Guihong;Peng, Jixing
关键词：
Irpex lacteus ; pyridine derivatives; furan derivatives; ACE inhibitory activity; molecular docking
