New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398
文献类型： 外文期刊
第一作者： Sun, Chunxiao
作者： Sun, Chunxiao;Ge, Xueping;Mudassir, Shah;Zhou, Luning;Che, Qian;Zhang, Guojian;Gu, Qianqun;Zhu, Tianjiao;Li, Dehai;Yu, Guihong;Zhang, Guojian;Li, Dehai;Peng, Jixing;Peng, Jixing;Li, Dehai
作者机构：
关键词： Chaetomium globosum; azaphilone alkaloids; cytotoxicity; deep-sea-derived fungus
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN： 1660-3397
年卷期： 2019 年 17 卷 5 期
页码：
收录情况： SCI
摘要： Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A-C (1-3), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. N-glutarylchaetoviridins A-C (1-3) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (6-10) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines.
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