Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo

文献类型： 外文期刊

第一作者： Li, Shi-fang

作者： Li, Shi-fang;Gong, Mei-jiao;Sun, Yue-feng;Shao, Jun-jun;Zhang, Yong-guang;Chang, Hui-yun;Sun, Yue-feng;Shao, Jun-jun;Zhang, Yong-guang;Chang, Hui-yun

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关键词： Foot and mouth disease virus; Antiviral activity; Brequinar; Suckling mouse; in vivo

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：6.529； 五年影响因子：5.979 ）

ISSN： 0753-3322

年卷期： 2019 年 116 卷

页码：

收录情况： SCI

摘要： Foot-and-mouth disease (FMD) is one of the most highly contagious animal disease that affects cloven-hoofed animals. However, the FMD vaccine does not provide effective protection until adaptive immune protection elicited by the vaccination occurs. Therefore, an alternative application of antiviral agents for inhibition of the FMD virus (FMDV) is needed. Here, we demonstrated that brequinar could exhibit antiviral activity in swine kidney cells (IBRS-2 cells) infected with two different FMDV serotypes. Subsequently, in vivo activity of brequinar was confirmed in a mouse model of infection. Specifically, brequinar at a concentration of 50 mu g, provided 25% protection for 5 days following FMDV challenge. These results suggested that brequinar could be used as effective antiviral agent against FMD.

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